Folding@Home

Re: EggXpert Folding@Home Team

Seru — Sun, 22 Nov 2009 06:42:38 GMT

Sidicas:
Right. You can't do math problems while you're sleeping and neither can your computer.

I can do math in my sleep kthx

Re: EggXpert Folding@Home Team

products — Wed, 18 Nov 2009 23:15:43 GMT

Ahaha! at the last line, LOL! Whether I can do math problems when I'm awake is another thing...... LOL!

Thanks for explaining!

Re: EggXpert Folding@Home Team

Sidicas — Wed, 18 Nov 2009 20:28:17 GMT

products:
in what way distributing simulation operations to multiple computers can be of any help. So, more simulations can be done simultaneously?

Yup. They're studying multiple proteins simultaneously..

products:
Is that the whole point of it?

Protein simulation

products:
And by simulating they are trying to find matches between simulated results and protein conformations seen in known desease states?

Not exactly.. It's not possible to "see" some proteins fold since they can happen faster than a blink of an eye.. And even if you did "see" them in a microscope, you still have absolutely no idea what causes it to "fold".. So you'd have no idea what causes it to "misfold".. The problem of protein folding needs to be approached from two directions.. You have the people in the lab who can see proteins fold and misfold without much understanding at the atomic level of what's going on.. And then you have computers which are running atomic level simulations of protein folding that need to be connected to the bigger picture..

So the problems that they're having is

No matter how much you study something under a microscope, you can't really determine what's going on at the atomic level.. And just because you see something does not mean you have any idea why it happens or why it doesn't happen..
The amount of computation required to simulate everything at the atomic level is astronomical. You can't simulate every atom in somebody's entire brain at the atomic level to determine why they get alzheimer's, it would take computers thousands and thousands of years.. There's just too much computation...

So certainly Folding@home alone is not the answer..

And certainly scientists in a lab alone is not the anwer..

The problems of protein folding have traditionally been attacked from the right with scientists in a lab poking and prodding.. But no matter how much they look at it and how much they prod at it, they can't 100% determine why proteins fold or misfold because they can't see what's really going on behind the scene.. Even worse, these scientists can get millions and millions and millions of your dollars and no matter what they do, they may never find the solution using this method alone..

Folding@home starts the attack on the problem from the left.. Instead of starting at the bigger picture and doing guess&check to figure out why it's broken, you start at the absolute smallest level (subatomic) and then build your way up to larger and larger scales.

Despite folding@home and all the scientist's work, there's still this grey no-man's-land in the middle where folding@home doesn't reach and the scientists in the lab can't reach.. That's where the solution to the problem is.. However, with each passing day, folding@home clears up more of the grey area on the left and advancing technology in high end labs clear up the grey area on the right.. With the idea of eventually meeting in the middle somewhere where we can absolutely solve any protein folding problems no matter how big or small they are which with it comes the cures to hundreds of diseases..

Folding@home continually publishes papers and their findings.. Those papers combined with papers from scientific findings in the lab is where real break throughs in cures for these diseases happen..

products:
Second, hm... my coomputer is mostly sleeping caz I want to save power. This project will reuire my computer to be on all the time?

Yes.

products:
Of course, it's my computer and I will be able to turn it of when I want to, but I mean if my computer's sleeping, it won't be contributing in sleep right?

Right. You can't do math problems while you're sleeping and neither can your computer.

Re: EggXpert Folding@Home Team

products — Wed, 18 Nov 2009 19:33:57 GMT

Questions!!!

Okay, I read everything on the frist page, but I would like to know how using multiple computers can help. I understand the molecular biology or biochemistry of DNA, protein and protein foldeing, but what I don't get is where and in what way distributing simulation operations to multiple computers can be of any help. So, more simulations can be done simultaneously? Is that the whole point of it? And by simulating they are trying to find matches between simulated results and protein conformations seen in known desease states?

Second, hm... my coomputer is mostly sleeping caz I want to save power. This project will reuire my computer to be on all the time? Of course, it's my computer and I will be able to turn it of when I want to, but I mean if my computer's sleeping, it won't be contributing in sleep right?

Re: EggXpert Folding@Home Team

Sidicas — Wed, 18 Nov 2009 17:47:40 GMT

Since the latest updates to the nvidia drivers, I don't think you need dummy plugs any more..

Re: EggXpert Folding@Home Team

prtuc2 — Wed, 18 Nov 2009 04:11:30 GMT

Actually VM is required because VM smp folding is based on linux based which provided more points, most people who fold with their i7 use smp7 instead of 8, so the graphics card ppd won't drop. Just give you some idea how much bonus points actually rewarded http://foldingforum.org/viewtopic.php?f=55&t=11314.

Re: EggXpert Folding@Home Team

Kardon — Wed, 18 Nov 2009 03:44:16 GMT

prtuc2:
Kardon had you look at my other post about the new folding setup? If you have an i7 might as well take the advantage boost up your cpu score.

Wow that sounds like a lot of work when I have easy stuff I still need to do like get a dummy plug for my gtx295 to fold on both cores. Can I setup the -bigadv without a vm setup? Geuss I'll have to look into it. Thanks for the heads up

Re: EggXpert Folding@Home Team

prtuc2 — Tue, 17 Nov 2009 02:07:54 GMT

Kardon had you look at my other post about the new folding setup? If you have an i7 might as well take the advantage boost up your cpu score.

Re: EggXpert Folding@Home Team

Tekran — Tue, 17 Nov 2009 01:55:20 GMT

Thank you for the congrats, Kardon.

Re: EggXpert Folding@Home Team

Kardon — Mon, 16 Nov 2009 23:34:36 GMT

Thanks guys!

Grats Tekran for passing the big 1million.

And grats to prtuc2 for being the one who always remembers to pass out the grats lol.

O and grats too dsteenbock for kicking me out of the #1 spot for a while

Keep up all the good work guys!

Re: EggXpert Folding@Home Team

Tekran — Mon, 16 Nov 2009 23:15:49 GMT

Thanks, I hit the million point mark about a week ago but I was not going to make a big deal about it. When I looked last night, Kardon was between 8000-9000 points from the 2 million point mark. I was going to check after work and see if he had made it yet. Thanks for posting the congratulations.

Congrats to Kardon!!!

Re: EggXpert Folding@Home Team

prtuc2 — Mon, 16 Nov 2009 21:10:39 GMT

Congratulations to Kardon being the 1st person on eggxpert to reach 2 million points milestone and Tekran breaking 1 million points as well.

Re: EggXpert Folding@Home Team

GmsCool — Sun, 08 Nov 2009 20:43:53 GMT

Not bad at all

If you look at Kakostats, and filter it by only "active members" you get 27'th

Re: EggXpert Folding@Home Team

n0lxx — Sun, 08 Nov 2009 14:56:00 GMT

I just checked where I'm at in the Team Stats. I'm in 48th place. Right behind jsv35. About 3800 points behind him. Guess that's not to bad.

Re: EggXpert Folding@Home Team

Kardon — Sat, 25 Jul 2009 23:26:18 GMT

Sidicas:

If you ever want to get a UPS to protect your systems that are running 24/7 so they can keep going even when the power is out.. Definitely go with APC, their UPS systems are absolutely amazing and darn fun to play with. Even the 80 dolalr models let you use the PowerChute software (running great in 64-bit Vista here) to fine tune the exact voltages of when the UPS switches over to battery backup.. Really cool stuff.

I agree about APC, Have always had good luck with them.