I don't know about any headaches tied with SLI, considering It's just a click in the Nvidia Control Panel, or it is for me anyways. A true SLI set up involves 2 or 3 PCI-E x16 slots, a SLI chipset like the 500, 600, 700 series, and 2 or 3 nvidia cards that are SLI capable, and a PSU that can handle it.